Dispersive solid-phase extraction for preconcentration of Amlodipine in aqueous samples using Fe3O4@MWCNT- β cyclodextrin composite

Document Type : Original Article

Authors

• ali moghimi ¹
• Mostafa Shojai ²
• Milad Abniki ³

¹ Associated professor analytical chemistry Department of Chemistry, Varamin( Pishva )Branch Islamic Azad University, Varamin, Iran

² Department of Chemistry, Islamic Azad University, Varamin(Pishva) Branch, Varamin, Iran

³ Department of Resin and Additives, Institute for Color Science and Technology, Tehran, Iran

Abstract

In this reasearch, innovative techniques to exploit small amount of Amlodipine in solid phase in water sample through Multi Wall Nanotube- NH2 its measurements by visible spectrophotometry and ultra violet in biological samples has been used. These techniques are di phasic system, which donor phases are watery samples and recipient phase is Fe3O4@MWCNT- β cyclodextrin. The experiments have been performed in two extraction stages of Amlodipine watery samples desorption by using Ammonia solvent and desorption samples were put to spectrophotometry device UV-Vis for analysis. This is quick and easy method and is consistent with many of available instrumental techniques. Exploitation parameters such as, desorption organic solvent, donor and recipient pH, extraction time, desorption time, stirring time, donor phase volume and surfactant effect were optimized and quantitative evaluation and measurements were performed in optimal conditions. The mentioned techniques have many advantages such as: short extraction time, consumption of organic solvent, deleting previous experiments effect, low diagnosis level and high-condensed factors and diagnosis level for Amlodipine are 14.5 - (LOD) 7.5 µgL-1 respectively. Linear range.0.02-7.9 mgL-1 and rational standard deviation for Amlodipine were % 1.9 and R2=0.9989.

Keywords

• Amlodipine solid phase extraction
• Fe3O4@MWCNT-β cyclodextrin
• spectrophotometry

---